2026 Prescription Drug Event File Layout Updates
CMS is publishing an HPMS memo on September 30, 2025, titled “2026 Prescription Drug Event (PDE) File Layout Updates”. Accordingly, the updates made to the PDE Inbound and Outbound File Layouts will become effective January 1, 2026.
The 2026 PDE Inbound and Outbound File Layouts are published for your reference on the CSSC Operations website under File and Report Layouts, with the updated field names and new valid values reflected in red font.
In the event you have questions, please contact CSSC Operations at 1-877-534-2772 (option 2) or by email at csscoperations@palmettogba.com.
Last Updated: 09/30/2025